减少早期的烟雾暴露作为儿童多发性硬化症的预防策略:PEDIGREE研究的结果
Silvy Pilotto1, Angelo Ghezzi2, Stefania Maria Bova3
1Department of Neuroscience and Rehabilitation, Sant'Anna University Hospital, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy. silvy.pilotto@unife.it.
Neurology and therapy
|February 18, 2026
概括
现在和怀孕前,父亲吸烟与患儿多发性硬化症 (PedMS) 的风险更高有关. 减少父母的吸烟可能是防止导致PedMS的早期环境因素的一个关键策略.
科学领域:
- 环境流行病学环境流行病学
- 神经免疫学 神经免疫学
- 儿科神经学 儿科神经学
背景情况:
- 评估对多发性硬化症 (MS) 的环境影响是具有挑战性的,因为长时间的疾病延迟和回忆偏差,特别是对于周围暴露.
- 调查父母吸烟与儿科多发性硬化症 (PedMS) 之间的联系对于了解早期生命环境风险因素至关重要.
研究的目的:
- 检查家长吸烟与儿科多发性硬化症 (PedMS) 发病率之间的联系.
主要方法:
- 在意大利多中心PEDIGREE研究中使用PEQ-IT问卷收集前性数据.
- 招募了114例儿童多发性硬化症病例 (使用2013年克鲁普标准诊断,疾病持续时间≤5年) 和121名18岁以下的匹配对照.
主要成果:
- 在那些父亲是目前的吸烟者 (OR 1.94) 或在怀孕前3个月吸烟 (OR 1.79) 的孩子中,观察到PedMS的风险更高.
- 当父母都吸烟时,PedMS的风险显著增加 (OR2.03),如果父母都在怀孕前3个月吸烟时,风险最高 (OR10.79).
- 没有发现母亲吸烟与儿童多发性硬化症风险之间存在显著的关联.
结论:
- 现在和怀孕前,父亲吸烟似乎是儿童多发性硬化症的重要危险因素.
- 促进父母的无烟环境可能是一个可行的预防措施,防止早期生活中的环境因素导致MS易感性.
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