不同年龄段的阿尔多 - 列宁比率的最佳切断值,用于初级阿尔多的查
相关实验视频
Updated: Feb 20, 2026

06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
24.4K
Delin Li1, Haolin Song1, Minghui Gong1
1Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Journal of clinical hypertension (Greenwich, Conn.)
|February 18, 2026
概括
查原发性阿尔多斯质性 (PA) 需要特定于年龄的阿尔多斯质与素比率 (ARR) 截止值. 最佳ARR值随着年龄的增长而增加,为50岁以下患者推2.4,为50岁及以上患者推3.7.
科学领域:
- 内分泌学 在内分泌学.
- 高血压研究 高血压研究
- 临床诊断 临床诊断 临床诊断
背景情况:
- 原发性阿尔多斯顿主义 (PA) 是二次高血压的一个重要原因.
- 精确的PA查对于及时诊断和治疗至关重要.
- 阿尔多与的比率 (ARR) 是一个关键的查生物标志物,但最佳切断值可能有所不同.
研究的目的:
- 在查原发性阿尔多斯泰龙症 (PA) 时,为阿尔多斯泰龙与雷宁比率 (ARR) 建立特定年龄的最佳切断值.
- 评估不同年龄层的统一ARR截止值的诊断性能.
主要方法:
- 对281名确诊的PA患者和1242名基本高血压 (EH) 患者的分析.
- 患者被分为四个年龄组:≤39,40-49,50-59和≥60岁.
- 采用接收器操作特征 (ROC) 分析来确定最佳的ARR切线,并评估诊断准确性.
主要成果:
- 在PA和EH组中观察到ARR和年龄之间的正相关性.
- 针对各年龄组 (≤39,40-49,50-59,≥60岁) 的最佳年龄特异性ARR切线被确定为2.3,2.8,3.1和3.6.
- 统一的ARR切线值为2.4,在50岁以下的患者中显示出高灵敏度和特异性,而3.7对于50岁及以上的患者更适合.
结论:
- 对于PA查的最佳ARR切断值随着年龄的增长而显著增加.
- 实施年龄分层的ARR截止值 (2.4年50岁以下,3.7年50岁以上) 可以提高PA查的诊断性能.
- 这些发现支持基于患者年龄的原发性阿尔多斯特隆症个性化查策略.
相关概念视频
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
265
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
265
Serum Studies: Renal Function Tests
474
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
474
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
256
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
256
Hormonal Regulation
36.3K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
36.3K
Pharmacodynamics in Geriatric Patients: Effects of Age
253
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
253
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
272
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
272

