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Updated: Feb 20, 2026

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在FLOW试验中,按慢性病严重程度分类的Semaglutide的脏和生存结果

Katherine R Tuttle^1,2, Johannes F E Mann^3,4, Manuel M Mayrdorfer⁵

¹Division of Nephrology, University of Washington School of Medicine, Seattle, WA, USA.

Clinical journal of the American Society of Nephrology : CJASN

|February 18, 2026

概括

在2型糖尿病和慢性病患者中,塞马格卢提德显著降低了病的进展和死亡. 在FLOW试验中,在病严重程度的不同阶段观察到这些好处.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
内分泌学在内分泌学.
临床试验临床试验

背景情况:

在2型糖尿病 (T2D) 和慢性病 (CKD) 患者中,塞马格卢提德在改善脏和整体存活率方面表现出有效性.
进行了进一步的分析,以量化这些好处在不同的CKD严重程度层.

研究的目的:

分析塞马格卢提德在降低不同程度的CKD的T2D患者病事件和死亡率方面的有效性.
通过基线eGFR和UACR定义的各个子组评估治疗效益.

主要方法:

FLOW试验是一项双盲,随机,安慰剂控制的研究,平均随访时间为3.4年.
患有T2D和特定的eGFR/UACR标准的参与者每周接受1毫克或安慰剂.
根据基线eGFR和UACR水平进行了子组分析.

主要成果:

塞马格卢提德将主要病事件的初级复合结果降低了24% (HR 0.76) 和全因死亡率降低了20% (HR 0.80).
对于主要结果和死亡,治疗效应在eGFR子组中一致.
在UACR≥2000 mg/g亚组 (HR 0.47) 观察到死亡风险显著降低.

结论:

塞马格卢提德有效降低了T2D患者患有CKD的主要病事件的风险和全因死亡率.
塞马格卢提德的益处跨越了CKD严重程度的范围,包括晚期.
这些发现支持对T2D患者的塞马格卢提德的使用.

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