诊断前甲状腺功能障碍和卵巢癌风险和生存率:一个前性队列研究
Azam Majidi1, Sabina Rinaldi1, Therese Truong2
1Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), Hormones and Metabolism team, Lyon, France.
Journal of the National Cancer Institute
|February 18, 2026
概括
甲状腺功能低下可能会降低卵巢癌的风险,而甲状腺功能过高可能会增加. 在这项研究中,甲状腺功能障碍不会影响卵巢癌诊断后的生存率.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 癌症流行病学 癌症流行病学
背景情况:
- 甲状腺激素会影响与卵巢癌相关的途径.
- 关于甲状腺功能障碍和卵巢癌的流行病学数据有限且不一致.
- 这项研究调查了甲状腺功能障碍与卵巢癌风险和存活率之间的联系.
研究的目的:
- 为了检查医生诊断的甲状腺功能障碍与卵巢癌风险之间的关联.
- 评估甲状腺功能障碍对卵巢癌存活率的影响.
- 为了澄清甲状腺功能障碍和卵巢癌的流行病学证据.
主要方法:
- 对80348名女性进行前性队列研究 (E3N队列).
- 通过两年一次的甲状腺功能障碍调查问卷 (1992-2014) 收集的数据.
- 用于分析卵巢癌发病率和存活率的考克斯回归模型,调整为混因素.
主要成果:
- 在诊断前甲状腺功能障碍和卵巢癌风险之间没有总体关联.
- 在5年前诊断的甲状腺功能低下症与风险降低有关 (HR=0.65).
- 在5年前诊断的甲状腺功能障碍症 (没有levothyroxine) 与风险增加有关 (HR=1.70).
- 在甲状腺功能障碍和卵巢癌存活率之间没有发现显著的关联.
结论:
- 甲状腺功能低下可能与卵巢癌风险降低有关.
- 甲状腺功能障碍可能与卵巢癌风险增加有关.
- 甲状腺功能障碍似乎没有影响诊断后的生存率.
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