相关实验视频

Updated: Feb 20, 2026

Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice

Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice

Published on: September 13, 2016

以细胞分辨率对人类肝脏组织进行3D重建

Wesley B Fabyan^1,2, Chelsea L Fortin^1,2,3, Dorice L Goune^1,2

¹Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.

Science advances

|February 18, 2026

概括

三维重建显示,肝硬化会破坏正常的肝脏结构,导致鼻状调节失调和网络分裂. 这种3D分析为肝硬化病理生物学和潜在的治疗方法提供了新的见解.

科学领域:

肝病学肝病学是一种肝病学.
病理学病理学病理学
医疗成像医学成像

背景情况:

肝脏的微观结构对于功能至关重要; 结构上的破坏是病理性的.
二维 (2D) 组织病理学在捕捉复杂的3D肝脏结构方面存在局限性.
了解3D肝脏结构对于诊断和治疗肝脏疾病至关重要.

研究的目的:

创建非纤维化和肝硬化人类肝脏组织的详细3D重建.
用先进的成像技术分析肝硬化肝脏的结构变化.
为了确定与肝硬化相关的特定结构变化.

主要方法:

采用了免疫抑制和组织清除技术.
先进的显微镜和计算软件用于3D重建.
产生了人类肝脏组织 (非纤维化和肝硬化) 的多球体重建.

主要成果:

肝硬化患者的肝脏显示出鼻状区域失调.
观察到表达谷氨酸合成酶的中心周肝细胞的减少.
确定了中央静脉和肝动脉网络的回归,以及胆道网络的碎片化,这表明了亲移植化表型.

结论:

三维 (3D) 病理分析揭示了肝硬化人类肝脏的显著结构破坏.
观察到的变化表明,在肝硬化组织中存在一个亲移植化/分散化现象型.
进一步实施3D病理分析可以加深对肝硬化病理生物学的理解,并指导新的治疗策略.

更多相关视频

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis

Published on: February 25, 2022

DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis

DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis

Published on: September 28, 2021

相关概念视频

Gross Anatomy of the Liver

Gross Anatomy of the Liver

The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...

Liver Histology

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...