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Updated: Feb 20, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
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CDKL5通过液-液相分离调节激发性突触的可塑性

Mingjie Li1,2, Ziai Zhu1,2, Dan Li1

  • 1Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.

Proceedings of the National Academy of Sciences of the United States of America
|February 18, 2026
PubMed
概括

循环素依赖性酶类5 (CDKL5) 通过液-液相分离 (LLPS) 通过PSD95.5调节突触可塑性. 这种机制对于树突性脊柱扩大至关重要,并且在CDKL5缺乏症 (CDD) 中被破坏.

关键词:
在CDKL5中,CDKL5为CDKL5.树突性脊柱 树突性脊柱液态液态相隔离器 液态相隔离器后突触密度 后突触密度突触性可塑性 突触性可塑性

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