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Updated: Jul 30, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
06:52

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

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通过纯DNA编码的库进行增强的选,由Fmoc修改启用

Qiujin He1,2, Yanhui Wang1, Xiyuan Tang3

  • 1Biotech Drug Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Proceedings of the National Academy of Sciences of the United States of America
|February 18, 2026
PubMed
概括

研究人员为DNA编码库 (PDEL) 开发了一种新的净化方法,使得能够创建更长,更高纯度的疗法. 这一突破通过克服图书馆合成的先前局限性,推动了基于的药物发现.

关键词:
一个DNA编码的图书馆.DNA编码的类库库.氨基保护氨基保护穿透细胞的可以穿透细胞.酸查是指酸的查.

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Proofreading01:43

Proofreading

Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
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Covalently Linked Protein Regulators

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Genome Copying Errors

DNA replication is a well-evolved process that copies millions of base pairs with high fidelity during each cell division. Occasionally a wrong base or a long stretch of wrong bases may get added to the daughter strands. If the errors are left unchecked, cells might accumulate several mutations that might endanger their  survival. Therefore, the copying errors are checked and repaired at three levels.
Proofreading01:31

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme