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对视网膜疾病的生物类似抗血管内皮生长因子的有效性和安全性:系统性审查和元分析

Bhadra U Pandya¹, Andrew Mihalache¹, Ryan S Huang¹

¹Temerty Faculty of Medicine, University of Toronto, Ontario, Canada.

Retina (Philadelphia, Pa.)

|February 18, 2026

概括

生物相似的抗血管内皮生长因子 (VEGF) 注射显示了与视网膜疾病的抗VEGF治疗相比的安全性和视觉结果. 为了在不同人群中进行长期评估,需要进一步的研究.

科学领域:

眼科医生眼科眼科
药理学药理学是指药理学的学科.
生物技术是生物技术.

背景情况:

视网膜疾病如AMD,DME和RVO显著影响视力.
内抗血管内皮生长因子 (VEGF) 注射是标准的治疗方法.
生物相似的抗VEGF剂为参考产品提供了潜在的成本有效的替代品.

研究的目的:

进行系统审查和元分析,将生物类似抗VEGF药物的有效性和安全性与参考抗VEGF药物的比较.
为了评估接受这些治疗的患者的视觉敏度,视网膜厚度和不良事件发生率.

主要方法:

2015年1月至2024年9月期间发表的25项研究的系统综述和元分析.
在OVID MEDLINE,Embase和Cochrane图书馆进行的搜索.
随机效应模型用于元分析;乔安娜·布里格斯研究所 (JBI) 工具用于偏差风险 (ROB) 评估;证据确定性的GRADE标准.

主要成果:

在生物类似药和参考抗VEGF治疗之间,在最终视力敏度,视力敏度变化,最终视网膜厚度或视网膜厚度变化方面没有发现显著差异.
在12-63.6周的随访期间,两组的不良事件发生率也相似.
亚组分析 (RCT,观察研究,特定疾病和阿弗利塞普特和拉尼比祖马布等药物) 产生了一致的,非显著的发现,得到了中等到高确定性证据的支持.

结论:

生物相似的抗VEGF药物表现出与其用于治疗视网膜疾病的参考对应物相比,具有可比的安全性和视觉结果.
有证据表明,生物类似药是一种可行的治疗选择.
未来的研究应侧重于多样化的患者队列和延长的随访,以确认长期的安全性和有效性.

关键词:

一个自由的概念.抗-VEGFF的使用方法.生物类似物是什么意思糖尿病性黄斑胀糖尿病性黄斑胀神经血管与年龄相关的黄斑变性.拉尼比祖马姆是什么意思视网膜静脉封闭视网膜静脉封闭

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