在圣路易斯婴儿牙-晚年生命健康研究中,产前和产后早期的暴露和晚年成人认知功能
Ruby C Hickman1, Joyce J Y Lin1, Kaleigh A McAlaine1
1Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Neurology
|February 18, 2026
概括
早期接触可能会影响成年人的认知能力,特别是在女性身上. 第二个三个月的暴露与认知功能恶化有关,相当于女性的3年年龄差异.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 众所周知,儿童暴露会影响神经认知.
- 早期暴露于成年期的长期影响较少被了解.
- 这项研究调查了从产前期到产后早期的暴露.
研究的目的:
- 估计产前和产后早期暴露与晚年成人认知功能之间的关联.
- 检查这些关联中的特定暴露时间和基于性别的差异.
主要方法:
- 前性队列研究 (圣路易斯婴儿牙后期生命健康研究).
- 使用激光切除ICP-MS评估牙中的度 (产前和产后早期).
- 通过计算机电池测量晚年成年人的认知功能,并使用加权GEE分析数据.
主要成果:
- 分析了715名参与者 (平均年龄62岁); 52%是女性.
- 较高的第二季度暴露与较低的认知功能 (不包括词汇) 相关,每ppm0.07 SDs.
- 在女性中发现了显著的关联:1ppm更高的与0.16SDs更差的认知功能有关,相当于3年的年龄差异.
结论:
- 提示性证据将早期暴露与晚年成年人的认知功能联系起来,特别是在女性身上.
- 第二个三个月的暴露对长期认知结果最为关键.
- 这些发现突出了早期暴露的潜在性别特异性脆弱性.
相关概念视频
Cognitive Development During Adulthood
943
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
943
Longitudinal Research
13.5K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.5K
Longitudinal Studies
554
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
554
Environmental Influences on Intelligence
993
Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children...
993
Teeth
1.8K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
1.8K


