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Updated: Jun 22, 2026

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吸收和生物转化控制了活体斑马鱼胚胎模型中的反应性烯胺的毒性:对基于NAM的危险评估的影响

Nico Grasse1, Stefan Scholz2, Thorsten Reemtsma1,3

  • 1Department of Environmental Analytical Chemistry, Helmholtz-Centre for Environmental Research - UFZ, Permoserstraße 15, 04318 Leipzig, Germany.

Environmental science & technology
|February 18, 2026
PubMed
概括

由于化学多样性,烯胺的水生毒性差异很大. 将毒动力学纳入危险评估至关重要,因为斑马鱼胚胎揭示了这些电友化合物的以前未知的解毒路径.

关键词:
生物积累的生物积累生物转化是一种生物转化.他们是电友的电友.新方法方法论新方法方法论氧化应激是一种氧化应激.反应性毒性反应性毒性水水水的水水的水

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...