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通过二次药优化为双重疾病量身定制cariprazine

Caleb D Vogt1, Julie Sanchez2, Alessandro Bonifazi3

  • 1Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse - Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, MD, 21224, United States.

European journal of medicinal chemistry
|February 18, 2026
PubMed
概括

新药候选药物在治疗并发性精神疾病和精神兴奋剂使用障碍方面表现有前途. 这些新型化合物提供了改善的多巴胺D3受体选择性,与cariprazine相比,可能减少副作用.

关键词:
双极性障碍是一种双极性障碍.比托普基连接体 比托普基连接体卡里普拉辛 (Cariprazine) 是一种这是可卡因可卡因.多巴胺D(2) 受体受体多巴胺D ((3) 受体受体双重障碍是一种双重障碍.大型抑郁症主要是抑郁症.甲基胺是一种甲基胺.精神兴奋剂使用障碍精神分裂症是一种精神分裂症.药物使用障碍物使用障碍物

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