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Updated: Feb 20, 2026

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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Published on: August 28, 2018

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对于PCSK9降解的双特异性阿巴LYTAC:对于胆固醇调节的一个有希望的策略

Shuaishuai Cui1, Mingjie Li2, Xiangjun Li2

  • 1School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, PR China; Central Laboratory, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030001, Shanxi, China.

Bioorganic chemistry
|February 18, 2026
PubMed
概括

我们开发了一种新型的DNA吸收体结构,该结构针对PCSK9 (proprotein convertase subtilisin/kexin type 9) 进行 lysosomal 降解. 这种方法提高了LDL受体的可用性,为治疗心血管疾病 (CVD) 提供了新的策略.

关键词:
两种特异性吸收体LYTAC LYTAC的两种特异性吸收体伊格菲里尔 (IGFIIR) 是一个国际贸易组织.在PCSK9中

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