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Updated: Feb 20, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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作为抗癌剂的triazole-substituted pyrazole-pyrimidine混合物:合成,细胞毒性,亡机制,以及基于JAB1向结构的设计

Fatma Albayrak Halac1, Zeynep Tugay Tulumcu1, Büsra Nur Aydın Kandemir1

  • 1Department of Chemistry, College of Basic Science, Gebze Technical University, 41400, Kocaeli, Türkiye.

Bioorganic chemistry
|February 18, 2026
PubMed
概括

合成了12种新的混合化合物,并对癌细胞活性进行了测试. 化合物4e显示出强烈的细胞毒性和诱导的亡,提供了一个有前途的双重作用抗癌策略. 进一步优化确定了潜在的JAB1准类型.

关键词:
阿米诺皮里米丁 (Aminopyrimidine) 是一种氨基胺.细胞灭亡 (apoptosis) 是一种死亡的过程.乳腺癌是什么? 乳腺癌是什么点击反应反应 点击反应反应.在JAB1中,JAB1是指JAB1.分子建模分子建模胰腺癌是一种胰腺癌.皮拉 (Pyrazole) 是一种可怕的药物.皮里米丁是什么 皮里米丁是什么这种药物是三醇.

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