一个多方面的工作流程,以推进对氧硫酸 (PFOS) 对人类的风险评估
Marija Opacic1, Darija Obradović2, Tijana Milićević2
1University of Novi Sad, Faculty of Sciences, Department of Biology and Ecology, Novi Sad, Serbia.
Journal of hazardous materials
|February 18, 2026
概括
这项研究使用器官毒性方法推进了对 perfluorooctane sulfonate (PFOS) 的人类风险评估. 它发现,体外转录组数据为PFOS风险提供了敏感的措施,为环境和饮食暴露限值提供了信息.
科学领域:
- 环境毒理学环境毒理学
- 风险评估 风险评估
- 毒素基因组学 毒素基因组学
背景情况:
- perfluorooctane sulfonate (PFOS) 是一种持久性环境污染物,具有潜在的人类健康风险.
- 现有的PFOS风险评估方法可能无法完全捕捉其毒理特征,特别是在体外数据中.
研究的目的:
- 开发和应用面向器官毒性的,以灵敏度为主导的工作流程,以推进PFOS对人类的风险评估.
- 为了将体外反应转化为人体等效剂量 (HED),并推导出转录组出发点 (PoD).
主要方法:
- 使用了以内皮细胞和肝脏球状体为重点的体外工作流.
- 使用基准度 (BMC) 建模和生理学基础毒动力学 (PBTK) 方法量化反应.
- 来自HEDs,转录的PoDs和风险查的人口水平超值百分位数.
主要成果:
- 毒基因组HED比尖端终点更敏感,内皮细胞和肝脏球体的中位数值.
- 特定范围内的HED引发了基因水平的反应,并参与了生物过程.
- 拟合的HED分布给出了内皮和肝脏的第5百分点PoDs.
- 血清PFOS水平表明一般和大多数职业队列的EP50效应幅度可以忽略不计,但有例外.
- 土壤+尘埃,鱼类和一些肉类超过了基于PoD的预测PFOS度,而乳制品和农产品通常低于响应范围.
结论:
- 开发的概率,HED定框架提供了一个透明的链接,从体外转录组学到人口层面的PFOS风险查.
- 这种方法可转移到其他具有可用的毒动力学和体外数据的和多基基物质 (PFAS).
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