结合物解决危害鉴定,将银杏酸作为新兴的自然污染物识别
Jie Bai1, Haoyang Liu2, Ming Zhao3
1State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, No. 38 Tongyan Road, Tianjin 300071, China; Guangzhou National Laboratory, No. 9 XingDaoHuanBei Road, Guangzhou International Bio Island, Guangzhou, Guangdong 510005, China; Division of Drug and Vaccine Research, Guangzhou National Laboratory, Guangzhou, Guangdong 510005, China.
Journal of hazardous materials
|February 18, 2026
概括
来自金科比洛巴的银科酸 (GA) 是新兴的自然污染物. GA C17:2被确定为高优先级的原原体,通过受损的脂质代谢和细胞应激通路引起肝脏和脏损伤.
科学领域:
- 环境毒理学环境毒理学
- 自然产品化学 自然产品化学
- 计算毒理学计算毒理学
背景情况:
- 来自金科比洛巴的银科酸 (GA) 是广泛存在的环境污染物.
- 对于原生物特异性危害和排毒器官影响的有限理解阻碍了风险评估.
- 由于监管漏洞和废物流入,气体是新兴的自然污染物.
研究的目的:
- 制定一个框架,优先考虑高关注的GA同源.
- 阐明GA诱导的肝脏和脏毒性的机械基础.
- 识别对公众和环境健康构成风险的特定GA原体.
主要方法:
- 综合网络毒理学,深度学习,分子对接,转录学和实验验证.
- 在 silico 危害预测和主要 GA 同源的优先级.
- 在体外细胞毒性测定和体内动物模型的短期暴露研究.
主要成果:
- GA C17:2 由于显著的in silico危险信号和蛋白质相互作用,被确定为高优先级的同源物.
- GA C17:2诱导细胞毒性,脂质新陈代谢干扰,以及肝脏和细胞中的铁亡,亡和炎症.
- 在体内研究显示,小鼠的肝脏和脏损伤与剂量相关,具有PPARA抑制和ACSL4上调.
结论:
- GA C17:2是一种显著的环境危害,通过特定的分子途径影响排毒器官.
- 开发的框架有效地识别了优先级高的新兴自然污染物.
- 调查结果支持加强GA的监测,分类和风险评估策略.
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