亚急性伊弗梅克丁诱导的情感失调:证据表明海马微质细胞和星球细胞激活
Mustafa Eser1, Cevşen Yazıcı2, Ümmühan Kandemir3
1Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Eskişehir, Türkiye.
Research in veterinary science
|February 18, 2026
概括
在大鼠中,高剂量伊弗梅克 (IVR) 导致焦虑和类似抑郁症的行为,以及海马神经炎症. 运动功能和认知仍然不受影响,突出显示了高剂量IVR的潜在风险.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 伊弗梅克丁 (IVR) 是一种抗寄生虫药物,由于血脑屏障 (BBB) 的原因,其透到中枢神经系统 (CNS) 是有限的.
- 诸如高剂量或受损的BBB等因素可以增加IVR的中枢神经系统入口,可能导致神经毒性.
研究的目的:
- 在大鼠中研究亚急性艾弗梅克丁暴露的行为和神经炎症影响.
- 评估ivermectin对运动功能,情感行为和认知的影响.
主要方法:
- 鼠每天接受21天内内注射ivermectin (1,5,或10 mg/kg) 的时间.
- 行为评估包括运动功能测试,升空加迷宫,强迫游泳测试和莫里斯水迷宫.
- 使用免疫组织化学分析海马组织以检测微质细胞和星球细胞激活.
主要成果:
- 甲没有影响运动性能或空间学习和记忆.
- 剂量为5和10毫克/千克的伊弗梅克丁诱导了焦虑和类似抑郁的行为.
- 10毫克/千克的剂量导致海马微质和星细胞激活 (增加Iba1和GFAP),而没有显著的神经元损失.
结论:
- 在大鼠中,低急性,高剂量的艾弗梅克丁暴露会导致情感行为变化和海马神经炎症.
- 这些影响发生在运动功能或认知表现没有可检测的损伤的情况下.
- 建议在高剂量的ivermectin时谨慎使用,特别是当BBB完整性受到损害时.
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