相关实验视频
Updated: Feb 20, 2026

09:36
Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
27.9K
量化美国肥胖的环境及其与肥胖的准因果关系:一个横截面双胞胎研究
Bram J Berntzen1, Ally R Avery2, Joline W J Beulens1
1Department of Epidemiology and Data Science, Amsterdam UMC, De Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Health Behaviors and Chronic Diseases, Amsterdam, the Netherlands; Upstream Team, Amsterdam UMC, De Boelelaan 1117, Amsterdam, the Netherlands.
Health & place
|February 18, 2026
概括
一个新的指数显示,肥胖引起的环境与更高的体重指数 (BMI) 之间存在联系. 然而,这种关联被遗传学等共同的家族因素所混,这表明环境本身并不能解释肥胖.
科学领域:
- 环境健康 环境健康
- 肥胖问题研究研究
- 双胞胎研究 双胞胎研究
背景情况:
- 肥胖是一种复杂的慢性疾病,受到生物学和环境的影响.
- 了解社区层面的肥胖原体暴露对于公共卫生干预至关重要.
- 家庭因素,包括遗传,在肥胖中起着重要作用.
研究的目的:
- 开发一个高分辨率的指数,结合肥胖的邻里暴露在美国 (OBCT-美国指数).
- 检查成年双胞胎的OBCT-US指数和体重指数 (BMI) 之间的关联.
- 评估家庭因素对环境-BMI关系的影响.
主要方法:
- 利用了来自华盛顿州双胞胎登记处的11,152名成年双胞胎的数据.
- 开发了美国Obesogenic Built Environment Characteristics (OBCT-US) 指数,包括食物环境,可行性,贫困和植被.
- 采用单变异双胞胎模型和线性回归,包括对单双胞胎 (MZ) 和同性双胞胎 (ssDZ) 双胞胎内对差异的分析.
主要成果:
- 体重指数表现出高遗传性 (74%),而OBCT-US指数主要受到独特的环境因素的影响 (63%).
- 在个人水平上,OBCT-US指数增加10%与BMI增加0.16kg/m2有关.
- 在MZ或ssDZ双胞胎对中,OBCT-US指数和BMI之间没有显著的关联.
结论:
- 更肥胖的社区环境与个体的BMI较高有关.
- 肥胖环境和BMI之间观察到的关联与共享的家族因素相混.
- 环境对BMI的影响可能不那么明显,当遗传和早期生活因素受到控制时.
更多相关视频
相关概念视频
Obesity
1.4K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.4K
Behavioral Genetics and Its Designs
1.2K
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.2K
Gene-Environment Interactions
1.3K
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
1.3K
Background and Environment Affect Phenotype
7.8K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.8K
Causality in Epidemiology
1.7K
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
1.7K
Heritability
679
Heritability is a statistical concept that measures the degree to which genetic differences among individuals contribute to trait variations within a population. It is a fundamental idea in genetics, often prone to misinterpretation. Heritability is expressed as a percentage, reflecting the proportion of variation in a specific trait across a population that can be linked to genetic differences. However, it's important to understand that heritability does not determine how "genetic"...
679

