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Xiaoshun Zhang¹, Shanshan Song¹, Qiuyi Ji¹

¹Department of Occupational Health and Occupational Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.

Ecotoxicology and environmental safety

|February 18, 2026

概括

高剂量的三二乙酸 (TCEP) 和 (Pb) 协同破坏斑马鱼的发育,影响脊椎和神经系统的生长. 这项研究强调了电子废物污染物对水生生态系统的风险.

科学领域:

环境毒理学环境毒理学
发育生物学是发展生物学.
神经科学是一个神经科学.

背景情况:

由于有毒污染物,电子废物 (电子废物) 构成重大环境和健康风险.
三二乙酸 (TCEP) 和 (Pb) 是具有已知的不良影响的关键电子废物污染物.

研究的目的:

研究TCEP和Pb暴露对斑马鱼早期发育的协同效应.
评估对死亡率,化,身体发育,神经发育和代谢途径的影响.

主要方法:

斑马鱼胚胎暴露于不同度的TCEP和Pb.
评估结果包括死亡率,化率,脊柱曲率,运动,身体长度和心率.
分析了神经发育基因表达 (qRT-PCR),神经递质水平 (ELISA),Pb吸收 (ICP-MS) 和代谢学.

主要成果:

高剂量的TCEP (35000μg/L) 与Pb (190μg/L) 结合显著增加脊柱曲率,抑制运动,减少身体长度和心率.
观察到脊髓和神经发育基因的下调,以及血清素 (5-HT) 水平的增加.
证实了协同效应,脂肪代谢途径发生显著改变,包括增加pld1和pld2基因表达.

结论:

对高剂量TCEP和Pb的联合暴露对斑马鱼早期发育产生协同作用的不利影响.
神经系统和脊椎是特别脆弱的,可能通过通过脂酶D路径中介于糖脂代谢中断.

关键词:

发展性毒性发展性毒性 (Pb) 是一种.代谢学代谢学代谢学 TCEP (三二乙烯) 酸盐) 的使用.斑马鱼是一种斑马鱼.

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