在转换为法里西马布后,在外泄性AMD患者中延长肠内注射间隔:多中心FAR WEST研究
A Posnic1, M Vaast2, A Poinas3
1Department of Ophthalmology, CHU de Rennes, Rennes University, 35000 Rennes, France.
Journal francais d'ophtalmologie
|February 18, 2026
概括
切换到法里西马布延长了新血管与年龄相关的黄斑变性 (nAMD) 患者的静脉内注射间隔,减少了排泄. 这种治疗提供了一个可行的选择,可以通过更长的无治疗期来管理nAMD.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 需要持续使用抗VEGF疗法治疗.
- 延长静脉内注射间隔 (IVI) 对患者的生活质量和治疗可持续性至关重要.
- 法里西马布是一种新型双特异性抗体,向血管蛋白-2和VEGF-A.
研究的目的:
- 评估转换为法里西马布是否能够在nAMD患者中延长IVI,而不会导致疾病复发 (排泄).
- 在切换到faricimab后,确定预测成功间隔延长的因素.
主要方法:
- 多中心,观察性回顾性队列研究 (FAR WEST).
- 包括nAMD患者在转换为法里西马布之前至少一年的先前抗VEGFIVI.
- 在基线 (M0) 和6个月后期 (M6) 收集的数据,以评估IVI,排泄和结果.
主要成果:
- 无复发性IVI间隔显著增加,从5.6周增加到7.2周 (P<0.0001).
- 排泄性患者的比例下降了37% (P<0.0001).
- 39%的先前耐火病例在M6获得了干色斑;立即延伸导致更长的间隔延伸.
结论:
- 切换到法里西马布有效地延长IVI,并减少nAMD患者的排泄.
- 在各种患者子组中观察到成功的间隔延长,包括那些没有接受加载阶段的患者.
- 需要进一步的前性研究来证实这些发现,并评估装载阶段的作用.
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