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Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
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迪努杜西马布相关的神经毒性:发生率,表现,危险因素和护理干预措施
Kristen L Dalton1,2, Erin A Armideo1, Shannon L Markert1
1Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Journal of pediatric hematology/oncology nursing
|February 18, 2026
概括
与dinutuximab相关的神经毒性在神经母细胞瘤治疗中很常见,影响大多数患者的早期. 尿和视觉变化是关键症状,普遍的危险因素表明需要有针对性的监测和干预措施.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 丁西马布是一种GD2定向的单克隆抗体,是神经母细胞瘤治疗的组成部分.
- 关于丁西马布诱导的神经毒性的发生率,风险因素和管理,存在重大知识差距.
研究的目的:
- 为了描述与dinutuximab相关的神经毒性症状.
- 总结治疗神经毒性的护理干预措施.
- 为了确定与dinutuximab相关的神经毒性的潜在风险因素.
主要方法:
- 在65名患者 (2018-2023) 进行了437次dinutuximab循环的回顾性描述性研究.
- 对患者人口统计,临床变量,神经毒性事件和护理反应的分析.
- 评估变量与神经毒性发生率之间的关联.
主要成果:
- 神经毒性发生在36.4%的周期中,影响了83.1%的患者,症状出现在早期 (73.7%的第一天).
- 常见的症状包括尿路滞留 (66.2%) 和视觉变化 (16.9%).
- 神经毒性与年龄,性别,前期与复发疗法或奎里评分没有显著的关系.
结论:
- 与dinutuximab相关的神经毒性是常见的,通常早期表现,并影响高比例的患者.
- 风险似乎是普遍的,不论是人口或临床因素.
- 针对性神经监测和护理干预措施的开发和测试对于安全的dinutuximab管理至关重要.
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