空间单细胞分析揭示了瘤微环境特征,可以预测口腔癌的结果
Joni Näsiaho1, Linda Nissi2, Sami Ventelä3
1MediCity Research Laboratory, University of Turku, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
Cell reports. Medicine
|February 18, 2026
概括
一种新的生物标志物,即生殖的淋巴内皮细胞 (KI67+PROX1+),可以预测早期口腔状细胞癌 (OSCC) 的复发. 这一发现改善了口腔癌患者的预后识别,有助于治疗策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 口腔状细胞癌 (OSCC) 的术后复发率很高.
- 目前的方法缺乏识别高风险早期OSCC患者的参数.
- 瘤微环境在OSCC进展中的作用需要进一步调查.
研究的目的:
- 确定早期OSCC瘤微环境中的预后生物标志物.
- 研究特定细胞表型与患者生存结果之间的关联.
- 验证一种用于预测OSCC无复发生存的新生物标志物.
主要方法:
- 使用图像质细胞计对>700,000个细胞进行空间分辨的单细胞分析.
- 对25种蛋白标记物的分析,以识别不同的细胞表型.
- 在独立的OSCC队列中使用KI67+PROX1+免疫染和生存分析进行验证.
主要成果:
- 确定白细胞和内皮细胞表型作为OSCC存活的独立预后因素.
- 在侵袭性边缘发现增殖的淋巴内皮细胞 (KI67+PROX1+) 作为不良无复发生存率的强有力的预测因素.
- 证实了KI67+PROX1+细胞在跨多个生存终点的独立队列中的预后价值.
结论:
- 瘤微环境,特别是扩散的淋巴内皮细胞,在OSCC进展中发挥着关键作用.
- KI67+PROX1+生物标志物为识别高复发风险的早期OSCC患者提供了有价值的工具.
- 这些发现对完善治疗策略和改善OSCC患者的治疗结果有潜在的影响.
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