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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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治疗脑瘤的细胞疗法:前60年

Sanya Mehta1, Giedre Krenciute2, Stephen Gottschalk2

  • 1Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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细胞免疫疗法,包括T细胞和自然杀伤细胞,在治疗原发性脑瘤方面表现有前途. 早期的研究表明安全性和持久的反应,特别是在与其他治疗结合时.

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科学领域:

  • 神经瘤学神经瘤学
  • 免疫学 免疫学 免疫学
  • 癌症研究 癌症研究

背景情况:

  • 初级脑瘤是极具致命性的癌症,治疗选择有限.
  • 免疫疗法为克服当前治疗局限性提供了一个有希望的途径.

研究的目的:

  • 为提供针对脑瘤的细胞免疫疗法的历史审查.
  • 总结已发表的研究中的临床经验和关键发现.

主要方法:

  • 自20世纪60年代末以来的早期临床试验的审查.
  • 对在脑瘤患者中测试的各种细胞免疫疗法方法的分析.

主要成果:

  • 早期使用非特异性白细胞,PBMC和骨髓细胞的研究表明安全性和偶尔的持久反应.
  • 随后的方法包括LAK细胞,TILs,ex vivo扩展的T细胞,NK细胞和CAR T细胞.

结论:

  • 在过去的60年里,采用细胞疗法已经有了显著的进化.
  • 细胞免疫疗法显示出治疗脑瘤的潜力,特别是在组合或预先设置的情况下.