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治疗脑瘤的细胞疗法:前60年

Sanya Mehta¹, Giedre Krenciute², Stephen Gottschalk²

¹Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Cell reports. Medicine

|February 18, 2026

概括

细胞免疫疗法,包括T细胞和自然杀伤细胞,在治疗原发性脑瘤方面表现有前途. 早期的研究表明安全性和持久的反应,特别是在与其他治疗结合时.

科学领域:

神经瘤学神经瘤学
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

初级脑瘤是极具致命性的癌症,治疗选择有限.
免疫疗法为克服当前治疗局限性提供了一个有希望的途径.

研究的目的:

为提供针对脑瘤的细胞免疫疗法的历史审查.
总结已发表的研究中的临床经验和关键发现.

主要方法:

自20世纪60年代末以来的早期临床试验的审查.
对在脑瘤患者中测试的各种细胞免疫疗法方法的分析.

主要成果:

早期使用非特异性白细胞,PBMC和骨髓细胞的研究表明安全性和偶尔的持久反应.
随后的方法包括LAK细胞,TILs,ex vivo扩展的T细胞,NK细胞和CAR T细胞.

结论:

在过去的60年里,采用细胞疗法已经有了显著的进化.
细胞免疫疗法显示出治疗脑瘤的潜力,特别是在组合或预先设置的情况下.

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