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在使用全基因组测序的病毒性脏病接受者中,BK多瘤病毒的遗传多样性和进化

Julien Gras^1,2,3, Marie Laure Nere⁴, Julien Robert⁵

¹Infectious Disease Department, APHP-Saint-Louis Hospital, Paris, France.

The Journal of infectious diseases

|February 18, 2026

概括

BKPyV病毒种群在移植后进化,不同的菌株存在早期和APOBEC驱动的突变,这有助于在BKPyVN患者中观察到的变化.

科学领域:

病毒学病毒学
移植免疫学移植免疫学
遗传学是一个遗传学.

背景情况:

结核多重瘤病毒 (BKPyV) 相关病 (BKPyVN) 是移植接受者 (KTR) 的一个重大并发症.
在KTR中BKPyVN复制和基因进化的动态与BKPyVN仍然不完全理解.

研究的目的:

在被诊断患有BKPyVN的移植接受者中调查BKPyV的遗传多样性和进化模式.
了解导致BKPyVN发展的病毒动态.

主要方法:

32个KTR与活检证明的BKPyVN的回顾性分析.
从血和脏活检样本中对BKPyV进行全基因组测序 (WGS).
对病毒载量,遗传亚型和序列变异的分析,包括与APOBEC相关的突变.

主要成果:

最常见的是 BKPyV I 基因型,其次是 IVc2 和 II.
在诊断时,血和BKPyV之间具有很高的序列相似性 (>99%),并注意到单核酸多态性.
在BKPyVN诊断之前检测到的病毒群体转移和少数变体 (VP1) 的证据.

结论:

BKPyV病毒种群是动态的,并且随着时间的推移在KTR与BKPyVN.中发生变化.
通过APOBEC介导的编辑和复制驱动的多样化都会在移植体内的病毒进化中发挥作用.
早期样本显示多个病毒群的共存,与BKPyVN诊断时的状态形成鲜明对比.

关键词:

在BK多重病毒中,BK多重病毒.腎臟移植腎臟移植病毒的多样性病毒的多样性病毒性病是一种病毒性病.整个基因组的测序.

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