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Updated: Feb 20, 2026

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
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针对催产素受体同质体的双对应带有选择性地激活不同的G蛋白和β-止素通路

Marta Busnelli1, Alessandro Gori2, Bice Chini1

  • 1Institute of Neuroscience, National Research Council, Vedano al Lambro (MB), 20854, Italy; NeuroMI Milan Center for Neuroscience, University of Milano-Bicocca, Milan 20126, Italy.

Biochemical pharmacology
|February 18, 2026
PubMed
概括

新型双价性催产素类似物 (dOTK) 通过稳定催产素受体 (OTR) 均代体,选择性地激活G蛋白和β-止素通路. 这为自闭症和精神分裂症中社会缺陷提供了一个新的治疗策略.

关键词:
有偏见的激进主义.G 蛋白质是一种蛋白质.同类生物价值联结体的联结体.同性恋者是同性恋者的人.催产素受体的受体 催产素受体β-阿雷斯类药物.

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