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一个小小的回顾. 维生素D用于预防2型糖尿病:证据和影响
Karin Amrein1, Sun H Kim2, Helmut Brath3
1Division of Endocrinology & Diabetology, Medical University of Graz, Austria.
Metabolism: clinical and experimental
|February 18, 2026
概括
维生素D补充剂可以帮助预防糖尿病前期的成年人患有2型糖尿病. 研究表明,它可以减少进展,改善葡萄糖调节,提供安全和负担得起的干预措施.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 糖尿病前期影响全球数百万人,为预防2型糖尿病提供了干预的关键窗口.
- 观察性研究将较高的25-基维生素D (25[OH]D) 水平与降低糖尿病风险联系起来.
- 维生素D具有可信的生物机制,影响β细胞功能,胰岛素敏感性和免疫力.
研究的目的:
- 评估维生素D补充剂在预防糖尿病前期糖尿病成年人2型糖尿病进展方面的疗效.
- 评估维生素D对葡萄糖调节的影响,并确定受益最多的子组.
主要方法:
- 一个单独的参与者数据元分析三个随机,双盲,安慰剂对照试验 (n=4190) 涉及糖尿病前期的成年人.
- 参与者接受了中度至高剂量的维生素D3或活性类似物.
主要成果:
- 维生素D补充剂导致2型糖尿病进展的相对风险降低15%.
- 较低基线25~OH) D水平和身体质量指数 (BMI) 低于30kg/m2的个体观察到更大的益处.
- 维生素D也增加了回归正常葡萄糖调节的可能性.
结论:
- 维生素D补充剂对于患有糖尿病前期的成年人来说是一种有效,安全和廉价的干预措施.
- 2024年内分泌学会指南建议维生素D用于糖尿病前期,即使没有例行25(OH) D测试.
- 需要进一步的研究来确认最佳的血液25~OH) D水平,以获得最大的益处.
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