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叶酸通过肠肌轴调节减轻酒精诱导的肉症

Nan Zhang¹, Jing Shi², Huaqi Zhang¹

¹Qingdao Medical College, Qingdao University, Qingdao, 266071, China.

Metabolism: clinical and experimental

|February 18, 2026

概括

叶酸 (FA) 补充剂可以通过改善肌肉质量和力量来预防酒精诱导的肉症. 通过调节肠肌轴,重新平衡肠道微生物群,并抑制肌素信号传递,FA起作用.

科学领域:

肌肉生理学和新陈代谢
肠道微生物组研究研究
营养生物化学营养生物化学

背景情况:

饮酒障碍经常导致肌肉功能障碍和肉症.
叶酸 (FA) 缺乏在慢性饮酒中很常见,可能会加剧肌肉损伤.
在酒精性sarcopenia中,FA通过肠肌轴在骨肌肉上的保护机制尚未完全理解.

研究的目的:

在小鼠中研究FA在预防酒精诱导的肉症的有效性.
阐明涉及肠肌轴的潜在机制,包括肠道微生物群和肌素 (MSTN) 信号传递.

主要方法:

小鼠接受了12周的酒精饮食,并补充了FA或idebenone.
实验包括体内MSTN操纵,便微生物群移植 (FMT) 和体外细胞培养.
分析包括肌肉质量,力量,组织学,线粒体功能,氧化应激,炎症,肠道微生物群和血清代谢学.

主要成果:

FA干预恢复了肌肉质量和力量,降低了同类半氨酸,并改善了线粒体功能.
FA降低了MSTN信号的调节,减少了蛋白质降解和增加了合成.
FA重新平衡了肠道微生物群和代谢物,因多硫酸盐 (IS) 被确定为关键调解物;FMT证实了肠道微生物群的作用.

结论:

通过准肠肌轴,FA有效地减轻了酒精性肉症.
FA 纠正酒精诱导的同型半氨酸失调,并增强线粒体功能.
通过重新平衡肠道微生物群-代谢物网络并抑制MSTN介导的蛋白质降解,FA恢复了肌肉蛋白质平衡.

关键词:

酒精性萨尔科佩尼亚 (酒精性萨尔科佩尼亚) 是一种叶酸是什么?叶酸是什么?叶酸是什么?肠 - 肌肉轴肠 - 肌肉轴通过MSTN介导的路径.通过多原子分析.

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