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严重的孕产妇发病率与子女脑风险增加有关

Asma M Ahmed¹, Bénédicte Driollet², Emmalin Buajitti³

¹Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

American journal of obstetrics and gynecology

|February 18, 2026

概括

孕产妇严重发病率 (SMM) 显著增加了孩子患脑 (CP) 的风险. 这种关联涵盖了所有SMM亚型,包括高血压疾病,出血和败血症,强调需要加强婴儿监测.

科学领域:

生殖医学生殖医学
儿科神经学儿科神经学
公共卫生公共卫生

背景情况:

严重的孕产妇发病率 (SMM) 与不良的围产期结果有关,但其与儿童神经发育障碍 (如脑) 的关联需要进一步调查.
了解这些联系对于识别面临风险的人群和告知预防策略至关重要.

研究的目的:

调查严重孕产妇发病率 (SMM) 与后代脑 (CP) 风险之间的关联.
检查这些协会在SMM的不同亚型.

主要方法:

一项纵向队列研究包括加拿大安大略省 (2003-2019) 超过210万名活产儿.
在怀孕和产后期间使用基于诊断和程序代码的验证算法确定了严重的孕产妇病率 (SMM).
儿童脑 (CP) 通过诊断代码来定义,并使用波桑回归模型在2020年之前进行跟踪.

主要成果:

患有SMM的母亲生下的孩子有明显增加的脑风险 (调整后RR: 2.71).
所有研究的SMM亚型,包括高血压疾病,出血和败血症,都与CP风险增加有关.
怀孕期间的严重高血压疾病 (调整后RR:3.29) 观察到最强的相关性.

结论:

严重的孕产妇发病率是儿童脑的重要危险因素.
这些发现强调了优化母亲健康的重要性,以减轻儿童的长期不良结果.
建议加强对SMM母亲出生的婴儿早期CP症状的监测.

关键词:

这就是为什么CPCPCPCPCP 在QBA中,QBA是QBA.这是一个SMM,SMM.严重的孕产妇发病率脑性麻脑性麻是一种定量偏差分析分析量化偏差分析

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