默认模式网络连接与轻度认知障碍患者的执行和语言表现有关
Hamide Nasiri1, Behadad Mohammadtaheri1, Farbod Khosravi2
1Student Research Committee, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Neuroscience letters
|February 18, 2026
概括
默认模式网络 (DMN) 连接中断对阿尔茨海默病 (AD) 阶段的认知有不同的影响. 在轻度认知障碍 (MCI) 中,较弱的DMN连接与较差的执行功能和语言有关,但不是记忆.
科学领域:
- 神经科学是一个神经科学.
- 认知神经学 认知神经学
- 神经成像是一种神经成像.
背景情况:
- 在阿尔茨海默病 (AD) 中观察到默认模式网络 (DMN) 连接性改变.
- 在AD连续体中,DMN功能连接和独特的认知领域之间的特定关系尚未完全理解.
研究的目的:
- 调查前后DMN功能连接和记忆,执行功能和语言表现之间的关联.
- 为了检查这些在认知正常,轻度认知障碍 (MCI) 和AD群体之间的关系.
主要方法:
- 从154名参与者的静止状态fMRI数据的横截面分析 (61个对照组,68个MCI,25个AD).
- 在前部 (aDMN) 和后部 (pDMN) 的前部 (aDMN) 和后部 (pDMN) 分区中,从兴趣区域与声元相关性得出的DMN连接度指标.
- 多重线性回归用于评估DMN测量和认知得分之间的关联,对共变量进行调整,并对多重比较进行校正.
主要成果:
- 在任何组中,DMN连接和记忆性能之间没有发现显著的关联.
- 在MCI组中,较弱的前后DMN连接与较差的执行功能和语言表现相关.
- 这些DMN-认知关联是MCI组的特异性,在认知正常或AD组中没有观察到,即使对白质超强度进行了调整.
结论:
- DMN连接-认知关系是域特定的,在MCI阶段最突出.
- 研究结果表明,MCI中网络水平功能组织的改变与特定的认知缺陷有关.
- 这突出了MCI作为DMN完整性可以预测认知结果的过渡阶段.
关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.认知能力下降 认知能力下降默认模式的网络模式是默认模式.执行职能 执行职能 执行职能功能连接性的功能连接性.轻度认知障碍 轻度认知障碍功能磁力共振成像 (fMRI) 是一种更多相关视频
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