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岛内皮层中的围神经网络塑造了糖尿病中与突出相关的行为

Giada Mascio¹, Roxana Paula Ginerete², Serena Notartomaso¹

¹IRCCS Neuromed, Pozzilli, Italy.

Neurobiology of disease

|February 18, 2026

概括

糖尿病改变了大脑的连接,影响了行为. 糖尿病小鼠在特定大脑区域增加的周神经网络 (PNN) 与行为变化相关,这表明岛内皮层的PNN驱动负显著性归因.

科学领域:

神经科学是一个神经科学.
代谢障碍代谢障碍代谢障碍
细胞外矩阵生物学细胞外矩阵生物学

背景情况:

糖尿病与中枢神经系统 (CNS) 功能连接变化和行为异常有关.
围神经网络 (PNN) 对于中枢神经系统网络活动至关重要,围绕着帕瓦胺阳性内部神经元.
PNN的变化可能是糖尿病相关的行为缺陷的基础.

研究的目的:

研究围神经网络 (PNN) 在与糖尿病相关的行为异常中的作用.
在糖尿病小鼠模型中,确定PNN密度在特定大脑区域的变化.
探索岛内皮层中PNN与与糖尿病有关的行为之间的因果关系.

主要方法:

在糖尿病小鼠和对照小鼠之间对关键大脑区域 (体感皮质,中间前额叶皮质,岛内皮质,杏仁体,网状乳头核) 的PNN密度进行比较分析.
在糖尿病小鼠岛皮层中PNN的酶降解.
行为测试包括机械疼痛值,冒险行为,社交互动,以及避开/避开模式.

主要成果:

糖尿病小鼠在体感皮质和中间前额皮质中表现出较低的PNN密度.
相反,PNN密度在糖尿病小鼠的岛内皮质,杏仁体和网状乳头核中增加.
在岛内皮层的酶性PNN降解正常化了社交互动和避开/避开行为,但没有影响疼痛或冒险.

结论:

糖尿病导致中枢神经系统内PNN密度的区域特异性变化.
岛内皮层中PNN的增加因果关系有助于改变对糖尿病负值的突出性归因.
针对岛屿皮层中的PNN可能为糖尿病相关的行为变化提供治疗策略.

关键词:

糖尿病糖尿病糖尿病岛屿皮层 (英语:insular cortex) 是一个岛屿皮层.周神经网络是什么?周神经网络与突出相关的行为链条毒素 (Streptozotocin) 是一种毒素.

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