在艾滋病毒感染者中,SARS-CoV-2变种特定的保护性免疫和长期免疫恢复:一项回顾性队列研究
Qingqing Ma1, Linhong Yao2, Haibo Ding2
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, NHC Key Laboratory of AIDS Immunology, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, China Medical University, Shenyang, 110001, China; Research Unit of Medical Laboratory, Chinese Academy of Medical Sciences, The First Hospital of China Medical University, Shenyang, 110001, China; Department of Clinical Laboratory, State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.
与没有艾滋病毒的人相比,感染艾滋病毒的人 (PLWH) 对SARS-CoV-2 Omicron变种的抗体反应中和较弱. 在PLWH中较低的抗体水平预测CD4+T细胞恢复较差.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 有效的交叉变异免疫对于携带艾滋病毒的人 (PLWH) 面临不断演变的SARS-CoV-2菌株至关重要.
- 了解PLWH在Omicron感染后的幽默免疫反应对于管理其健康结果至关重要.
研究的目的:
- 在Omicron BA.5.2/BF.7突破性感染后,对PLWH的变异特异性幽默免疫反应进行调查.
- 评估这些免疫反应与疾病进展之间的关联,包括CD4+T细胞恢复.
主要方法:
- 在Omicron BA.5.2/BF.7爆发期间招募了455名PLWH和91名没有艾滋病毒的人 (PWOH).
- 感染后3-6个月收集的外周血液样本用于针对19种SARS-CoV-2变种的中和抗体 (NAb) 测试.
- 进行了一年的临床随访,以监测疾病的进展.
主要成果:
- PLWH产生了广泛反应的NAbs,但在低于PWOH的水平,即使具有类似的感染/接种疫苗史.
- 野生型疫苗接种促进了对早期变异的NAbs,但对晚期Omicron变异的活性仍然有限.
- 具有CD4+T细胞计数<350细胞/μL的PLWH显示NAb标位和多样性降低;基线NAb水平与晚期Omicron变异相比预测CD4+T细胞恢复.
结论:
- 结果突出显示PLWH中对SARS-CoV-2 Omicron变异的中和抗体反应减少.
- 对晚期Omicron变异的基线NAb水平可以预测PLWH的长期免疫恢复 (CD4+T细胞计数).
- 结果可以在未来的SARS-CoV-2变种爆发期间为PLWH提供临床管理策略.
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