萨库比特里尔/瓦尔萨尔坦作为心脏辐射保护器
Mihaela Ghita-Pettigrew1, Brianna N Kerr1, Kathryn H Brown1
1The Johnston Cancer Research Centre, Queen's University Belfast, Jubilee Road, Belfast, Northern Ireland.
萨库比特里尔/瓦尔沙坦 (sac/val) 通过改善小鼠的心脏功能和结构,有望保护心脏免受辐射损伤 (RHI). 该药物在动物模型和接受胸部辐射治疗的患者中耐受性良好.
科学领域:
- 心脏病学 心脏病学
- 辐射瘤学 辐射瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 尿酸在辐射心脏损伤 (RHI) 中的作用尚未得到充分研究.
- 初步数据将RHI与心房 natriuretic (ANP) 的降低联系起来.
- 萨库比特里尔/瓦尔萨坦 (sac/val) 调节尿素系统,改善心力衰竭的结果.
研究的目的:
- 为了评估sacubitril/valsartan (sac/val) 作为抗辐射心脏损伤的辐射保护剂.
- 在RHI的小鼠模型中研究sac/val的安全性和初步疗效.
- 在接受胸部辐射治疗的患者中探索ANP动态和sac/val安全.
主要方法:
- 使用了一种部分心脏辐射小鼠模型,小鼠接受了带有或没有sac/val.的辐射.
- 在30周内,通过心声学和心电学评估心脏功能和结构.
- 测量了血ANP水平,并对患者的ANP动态和囊/安全性进行了回顾性临床系列检查.
主要成果:
- 在被辐射的小鼠中,囊/囊显著改善了心脏重塑,缩/放缩功能和电生理学参数.
- 通过sac/val的功能性心脏保护早在辐射后10周就显而易见.
- 在动物和患者中,Sac/val被很好地容忍,没有报告任何不良反应. 临床数据表明,在放射治疗期间,ANP有动态变化.
结论:
- 在临床前的模型中,sacubitril/valsartan (sac/val) 有效地减轻了结构和功能辐射心脏损伤.
- 在动物和早期临床研究中,该药物在与辐射联合使用时表现出良好的耐受性.
- 进一步研究sac/val作为心脏辐射保护剂的潜力是有必要的,得到了观察到的ANP动态和安全概况的支持.
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