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Updated: Feb 20, 2026

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核体中变化的[a]烯 adduct 形成在肺癌中建立了独特的突变模式

Benjamin Morledge-Hampton1, Markus Lindberg2, Erik Larsson2

  • 1School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA.

The Journal of biological chemistry
|February 18, 2026
PubMed
概括

烟草烟雾中的[a]二醇环氧化物 (BPDE) 会导致肺癌. 在核子体中抑制BPDE adduct形成,但在链接DNA中丰富,解释了肺癌突变模式.

关键词:
在 BPDEDE 中,尼尔·内尔 (NER NER NER) 是一个国家.肺癌是一种肺癌.核细胞是核细胞的组成部分.转录因子是一种转录因子.

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