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Updated: Feb 20, 2026

Monitoring Protein Aggregation Kinetics In Vivo using Automated Inclusion Counting in Caenorhabditis elegans
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该Hsp40辅助组DNAJC7调节多重胺聚合,并对多重糖氨酸聚合表现出上下文依赖的影响

Biswarathan Ramani1, Kean Ehsani1, Martin Kampmann2

  • 1Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.

The Journal of biological chemistry
|February 18, 2026
PubMed
概括

研究人员开发了新的细胞模型来研究多重胺 (polyQ) 和多重甘油 (polyG) 疾病中的蛋白质聚合. 鉴定出Hsp40辅助组DNAJC7是聚Q聚合的关键抑制剂,也影响着聚G聚合.

关键词:
聚合方式 聚合方式 聚合方式陪伴者是一个陪伴者.高通量选的高通量选神经退行症的神经退行症多重谷氨胺的疾病多重谷氨胺的疾病

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