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Generation of Alginate Microspheres for Biomedical Applications
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基于滴滴的微封装使用一种新的阿曼/酸盐系统:配方,表征和封装效率.

Asmaa Al-Hamayda1, Mutammed Ayyash2, Pedro Fardim3

  • 1Department of Chemical & Petroleum Engineering, United Arab Emirates University, PO Box, 15551, Al Ain, United Arab Emirates.

International journal of biological macromolecules
|February 18, 2026
PubMed
概括

奥曼 (OG) /酸盐复合珠显示出可以提供口服蛋白质的前景. 这些新的生物聚合物珠子提供持续释放牛血清白蛋白 (BSA),突出 Boswellia sacra 作为可持续的封装剂.

关键词:
牛血清中的牛血清蛋白.水凝珠子的珠子微封装是一种微封装.奥曼人的口香糖.提供蛋白质的蛋白质输送.

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科学领域:

  • 生物材料科学 生物材料科学
  • 制药科学 制药科学
  • 药物运输 药物运输 药物运输

背景情况:

  • 通过口服输送牛血清白蛋白 (BSA) 等蛋白质是具有挑战性的,原因是胃肠道的降解.
  • 生物聚合物矩阵具有保护和控制治疗蛋白质释放的潜力.
  • 来自Boswellia sacra的阿曼 (OG) 是一种具有生物材料应用潜力的天然聚合物.

研究的目的:

  • 调查阿曼 (OG) /酸盐复合珠在体外口服输送BSA.的潜力.
  • 为了制造和表征新的生物聚合物珠子,以高效地封装蛋白质和控制释放.
  • 评估OG度对珠子特性和BSA释放动力学的影响.

主要方法:

  • 使用离子凝滴滴技术制造OG/酸盐复合珠.
  • 物理化学性质的表征,包括泽塔潜力,粒子大小和粘度.
  • 使用SEM,FTIR,XRD,TGA和DSC分析珠子形态,结构完整性和热性能.
  • 通过布拉德福德试验和UV-Vis光谱学在不同pH条件下对BSA释放配置的体外评估和量化.

主要成果:

  • 强烈的OG和藻酸盐 (SA) 之间的分子间相互作用增强了结构稳定性和持续的BSA释放.
  • 配方含有40%的OG (Blend B) 在中性pH下显示延迟,持续释放,早期释放最小.
  • 含有50%OG (混合C) 的配方表现出最佳的热稳定性,均的几何形状和平衡的释放行为.

结论:

  • 奥曼 (OG) 是一种有前途的天然和可持续的蛋白质封装剂.
  • 甲基/酸盐复合珠显示出有效的蛋白质如BSA.的体外口服输送的潜力.
  • 这些发现支持OG/SA矩阵在制药和营养品蛋白质输送系统中的应用.