在心力衰竭患者中,sarcopenia组件的性别特异性预后模式
Aki Habaguchi1, Satoshi Katano2,3, Toshiyuki Yano4
1Graduate School of Medicine, Sapporo Medical University.
概括
基于表现的萨尔科佩尼亚测量预测了心力衰竭 (HF) 患者的死亡率,无论性别如何. 然而,标准肌肉质量值可能低估了女性的风险,这表明需要针对性别进行调整.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 肌肉生理学 肌肉生理学
背景情况:
- 衰老的一个组成部分 - - 萨科佩尼亚 - - 在心力衰竭 (HF) 中越来越多地被认可.
- 在HF患者中,萨科佩尼亚组件的预后价值和潜在的性别差异尚未完全理解.
研究的目的:
- 为了调查萨科佩尼亚成分是否为心力衰竭患者的死亡率提供性别特异的预后信息.
- 评估不同类型的萨尔科佩尼亚评估工具在预测HF患者死亡时的性能.
主要方法:
- 一组604名心力衰竭患者 (259名女性,平均年龄73岁) 接受了双能量X射线吸收计.
- 死亡率数据是在2.18年的中位数随访期间收集的.
- 评估了sarcopenia的组成部分,包括握手强度,五倍的坐站时间 (FTSS),短时间的体力表现电池 (SPPB) 和尾骨肌肉质量指数 (ASMI).
主要成果:
- 所有连续的sarcopenia变量都与总体队列中的死亡有关.
- 亚洲肉类症工作组 (AWGS2019) 对手握弱,长期FTSS和低SPPB的标准强烈预测死亡率;低ASMI没有.
- 虽然大多数成分没有显著的性相互作用,但手握强度趋向于女性更强的关联. AWGS2019标准预测男性的死亡,但女性的死亡没有.
结论:
- 基于表现的肉类症组件对HF患者的死亡风险分层有价值,无论性别如何.
- 人口来源的肌肉质量值表明女性的预后性能降低.
- 细化疾病特异性或适应性别的值可能会提高心力衰竭风险分层的准确性.
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