相关实验视频
Updated: Feb 20, 2026
08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.7K
在COVID-19之后,家族地中海热带呈现与反复出现的腹痛而没有周期性发烧:一个病例报告
Nobuhiro Ueno1,2,3, Hiromichi Sugai1, Suzumi Ujiie1
1Division of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Internal medicine (Tokyo, Japan)
|February 18, 2026
概括
家庭地中海热 (FMF) 可以表现为COVID-19后反复出现的腹痛,即使没有发烧. 使用生物标志物和基因检测的早期诊断对于有效的菌素治疗至关重要.
科学领域:
- 内部医学 内部医学
- 遗传学 是一个遗传学.
- 类风湿病学 类风湿病学
背景情况:
- 家庭地中海热 (FMF) 通常伴有周期性发烧.
- 非典型的FMF表现,特别是没有发烧,很少见,但已被认可.
- 感染后的后遗症可以模仿其他炎症状况.
研究的目的:
- 报告一种非典型的FMF病例,在COVID-19后呈现为复发性腹痛.
- 突出在这种情况下的诊断挑战和遗传检测的重要性.
- 强调生物标志物在诊断和监测FMF中的作用.
主要方法:
- 一个16岁女性的病例报告,在COVID-19后出现了反复复发的腹痛.
- 临床评估包括内镜检查,便calprotectin,血清粉样蛋白A和C反应蛋白.
- 对于MEFV突变的遗传测序.
- 治疗试验用. 科尔奇辛.
主要成果:
- 患者出现了反复出现的腹痛,腹征兆和胸腔溢液,但没有发烧.
- 检测发现便中calprotectin和血清中amyloid A的升高;C反应性蛋白保持正常.
- 经过MEFV基因测序,发现了同卵性E148Q突变,证实了非典型的FMF.
- 科尔奇辛治疗导致症状迅速消失和生物标志物的正常化.
结论:
- 这个案例说明了FMF模仿其他后感染性腹痛综合征的不寻常表现.
- 向生物标志物 (便calprotectin,血清粉样蛋白A) 和基因分析对于诊断非典型的FMS至关重要.
- 及时诊断和用黄素治疗对于管理FMF爆发至关重要.
相关概念视频
01:27Myocarditis II: Clinical Features and Diagnostic Tests
355
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
355
01:23Gastritis III: Clinical Manifestations and Management
1.4K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.4K
01:22Appendicitis-I: Introduction
2.7K
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
2.7K
01:19Pericarditis II: Clinical Features and Diagnostic Tests
378
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
378
01:26Patterns of Fever
4.0K
Before understanding the types and patterns of fever, it is essential to know its phases.
4.0K
01:17Gastritis-II: Pathophysiology
1.4K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.4K