肺部扩散氧化在疾病中的能力:一个范围审查.
Thomas Radtke1,2, Hà Pham-Ngoc3, Thong Hua-Huy3
1Division of Occupational and Environmental Medicine, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland thomas.radtke@uzh.ch.
概括
单呼吸肺扩散氧化 (D_LNO) 能力在检测各种疾病中的肺部变化方面表现有前途. 需要进行更大规模的研究才能充分理解D_LNO.
科学领域:
- 肺部生理学 肺部生理学
- 呼吸系统药物 呼吸系统药物
- 诊断技术 诊断技术 诊断技术
背景情况:
- 单呼吸肺部扩散氧化 (D_LNO) 容量是一个新兴的措施.
- 它在各种临床条件中的应用需要全面的映射.
研究的目的:
- 在各种疾病中对DLNO进行现有研究进行映射.
- 为了确定研究D_LNO.研究的研究差距.
主要方法:
- 使用了一个范围审查方法.
- 从1983年到2025年,主要的数据库 (Embase,MEDLINE,PubMed,Scopus,科学网,科克伦图书馆) 进行了系统的文献搜索.
- 使用Rayyan和REDCap进行了数据提取和选.
主要成果:
- 69项研究符合资格标准,涵盖呼吸,免疫,COVID-19后,心血管和代谢疾病.
- 研究设计中存在显著的异质性,样本规模小 (62.3%<50名参与者),缺乏注册的协议.
- D_LNO在检测间歇性/纤维性变化方面表现出敏感性,并且与D_LCO一起,确定了血管-血液学扰乱.
结论:
- 单呼吸D_LNO和D_LCO测量提供了对扩散阻力和血管血液学状况的见解.
- 需要进行更大规模,更精心设计的研究,以在不同疾病状态中建立对DLNO的明确解释.
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