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Updated: Feb 20, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
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针对格里索维里丁的总合成的研究

Carolina Caso1, Karl-Heinz Altmann1

  • 1Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 4, CH-8093 Zürich, Switzerland.

Organic letters
|February 18, 2026
PubMed
概括

研究人员合成了bis-macrolactam 5,这是格里索维里丁总合成的关键中间体. 这涉及木-米亚乌拉合,巴比尔型合,立体选择性减少和硫转移,产生一个灰维里丁模拟物.

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