在医院出院时,同时处方抗精神病药和二zepines
Maxime Demourgues1, Alexandre Richaud2, Julie Thiec2
1Hôpital Charles-Perrens, Bordeaux, France; Université de Bordeaux, INSERM, BPH, Team AHeaD, U1219, 33000 Bordeaux, France.
L'Encephale
|February 18, 2026
概括
常规镇静性抗精神病药物 (CS-AP) 与二类药物 (BZD) 的组合在精神病患者出院后很常见,特别是在短时间住院 (≤14天) 后. 这种高患病率引发了人们对患者安全和门诊环境中潜在的不良药物反应的担忧.
科学领域:
- 精神病学是一个精神病学.
- 临床药房 临床药房
- 药物监督 药物监督 药物监督
背景情况:
- 抗精神病药物和二类药物 (BZD) 携带镇静,头和认知障碍的风险,当结合,因为他们的精神病性质.
- 在精神病医院出院时,应尽量减少抗精神病药物和BZD的同时处方,特别是在常规镇静性抗精神病药物 (CS-AP) 方面,如胺,胺或洛沙.
研究的目的:
- 为了确定CS-AP,长期抗精神病药物 (LT-AP) 和精神病医院出院时BZD处方的患病率.
- 确定与CS-AP和BZD联合处方相关的因素.
主要方法:
- 追溯研究分析了2022-2023年精神病医院住院的出院处方.
- 通过在出院时注册抗精神病药物和BZD使用来评估患病率.
- 多变量逻辑回归用于识别与CS-AP和BZD联合处方相关的因素.
主要成果:
- 在5,733份处方中,38.7%包括CS-AP,69.1%是LT-AP,48.3%是BZD.
- CS-AP和BZD联合处方发生在14.8%的病例中,CS-AP,LT-AP和BZD发生在10.1%的病例中.
- CS-AP和BZD联合处方与较短的住院时间 (≤14天) 和最初的精神病急诊室入院有显著的关联.
结论:
- 在精神病诊所出院时,CS-AP与BZD联合处方的高患病率,尤其是在短期住院后,需要改善医院到社区护理的过渡.
- 由于可能出现不良药物反应,与BZD一起经常开处方的胺 (最常见的CS-AP) 需要谨慎使用.
- 短暂的住院和紧急住院可能会导致出院时的药物管理不足.
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