相关实验视频

Updated: Feb 20, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

移植患者的MBL2缺乏和IgA病:补充抑制是否总是有益的?

Emma Diletta Stea¹, Francesco Pesce², Ighli di Bari³

¹Unit of Nephrology, Dialysis, Transplantation, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.

European journal of internal medicine

|February 18, 2026

概括

与MBL2"O"等位基相关的低曼诺酶结合性莱克 (MBL) 水平与IgA脏病 (IgAN) 患者的移植存活率降低有关. 这种缺陷与增加的替代途径补充激活相关,影响了移植结果.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
免疫学免疫学免疫学
移植移植移植移植

背景情况:

IgA病 (IgAN) 是末期病的主要原因,通常需要移植.
曼诺结合性莱克 (MBL) 是莱克通路的组成部分,在IgAN中起着复杂的作用,缺乏和过量都可能使病情恶化.
MBL2基因的遗传变异会影响MBL水平和功能,可能会影响移植结果.

研究的目的:

为了研究MBL2变异,MBL水平,补充系统激活和Igan移植接受者的脏移植存活率之间的关系.
评估MBL2等位基因和delCFHR3-1状态对移植结果的综合影响.

主要方法:

分析MBL2变体,MBL血清水平和补充替代途径 (AP) 在64名Igan移植接受者的活性.
遗传数据和MBL水平与移植存活率和无事件存活率的相关性.

主要成果:

与野生型"A"等位基携带者相比,携带MBL2"O"等位基的患者的MBL血清水平显著降低,无事件存活率降低.
MBL 缺乏与替代途径 (AP) 补充活性增加有关.
这些发现表明,AP激活在异种移植功能障碍和Igan移植患者的移植存活率降低中的作用.

结论:

MBL2基因型和MBL水平评估可以为Igan移植接受者提供预后见解.
识别有风险的患者可能允许个性化治疗策略,潜在地针对特定的补充途径以改善结果.
这项研究挑战了普遍补充抑制益处的概念,建议基于个体补充通路活动的细微方法.

关键词:

补充系统的补充系统.在DelCFHR311 遗传学遗传学是一个遗传学.淋巴细胞突炎是什么?移植的生存率移植的生存率腎臟移植腎臟移植曼诺结合性莱克,MBL2 这是一种

更多相关视频

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Published on: July 25, 2014

相关概念视频

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...