肠道微生物群作为与前列腺癌相关的生活方式风险因素
Michael A Liss1, James R White2, Molly Doris3
1Department of Urology, University of California San Diego, CA, USA; Department of Surgery, South Texas Veterans Healthcare System, San Antonio, TX, USA.
European urology focus
|February 18, 2026
概括
一个新的肠道微生物组评分,PRIMUS,可以评估前列腺癌风险. 这种从微生物分析中获得的生物标志物,显示出在癌症预防中个性化生活方式修改的前景. 进一步的试验将探索微生物组的可变性.
科学领域:
- 微生物组研究的研究.
- 癌症生物标志物 癌症生物标志物
- 医学中的人工智能
背景情况:
- 缺乏个性化的前列腺癌预防策略.
- 肠道微生物群影响非胃肠道癌症,包括前列腺癌.
- 肠道微生物组分析可以识别由于生活方式因素而面临更高风险的个体.
研究的目的:
- 开发一种基于肠道微生物组的生物标志物,用于前列腺癌风险评估.
- 创建一个个性化的工具来识别容易患前列腺癌的个人.
- 探索肠道微生物群作为一种生活方式生物标志物的作用.
主要方法:
- 使用DNA测序和生物信息学进行微生物组风险分析.
- 确定了39个关键的微生物种类.
- 开发一种人工智能模型,使用微生物组理解 (PRIMUS) 评分 (0-1) 来生成前列腺癌风险洞察力.
主要成果:
- 增加的PRIMUS分数与前列腺癌风险的连续增加相关.
- 平均4.5年的随访后,前列腺癌风险仍然很高.
- 普林斯得分与现有的前列腺癌风险计算器相比,表达了有利的比较.
结论:
- 肠道微生物组可以作为前列腺癌的生活方式风险因素.
- PRIMUS评分是一个有前途的风险评估工具,但不是用于活检指导.
- 未来的临床试验将调查微生物组的可修改性,以减少前列腺癌风险.
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