精神分裂症情绪处理:脑成像研究的见解,比较患者,兄弟姐妹和健康的对照
Anna M Fiorito1,2,3, Ayman Kheireddine4, Hyemin Han5
1Université Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, PSYR2, Bron, France.
Human brain mapping
|February 18, 2026
概括
精神分裂症患者和他们的兄弟姐妹表现出情绪识别受损,在两组中都观察到右侧中后回形中大脑激活发生变化. 兄弟姐妹也表现出增加的杏仁核-核连接性,这可能表明处理负面面部情绪的补偿机制.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 异常的面部情绪识别是精神分裂症的潜在内分类型,影响患者及其亲属.
- 以前的功能磁共振成像 (fMRI) 研究存在局限性,包括使用中性刺激和对亲属大脑连接的有限探索.
- 了解情绪处理的神经相关性对于精神分裂症内分类型研究至关重要.
研究的目的:
- 研究精神分裂症患者及其兄弟姐妹的情绪处理神经机制.
- 在对负值面部表情的感知过程中,专注于大脑激活和功能连接.
- 通过使用生态有效的任务和检查连接模式来解决先前研究的局限性.
主要方法:
- 118名参与者 (37名精神分裂症患者,39名兄弟姐妹,42名健康对照) 接受了fMRI扫描.
- 参与者执行了一项情感任务,涉及负值面孔和控制条件.
- 使用平衡整合得分 (BIS) 评估行为表现;使用杏仁体作为种子区域,分析fMRI数据以激活和功能连接 (gPPI).
主要成果:
- 与对照组相比,患者和兄弟姐妹都有较低的BIS分数,表明行为表现受损.
- 兄弟姐妹在右上旋和右后中枢旋中表现出对负面面孔的脑反应下降.
- 贝叶斯分析表明,患者的右侧中枢后环激活受损;在杏仁体激活方面没有发现任何显著的群体差异. 兄弟姐妹表现出更强的右桃体-右骨连接.
结论:
- 对负面面孔的杏仁体反应在不同组中看起来是相似的,但在右侧的后中环中可能存在一个内表型模式.
- 基于激活的分析可能无法完全捕捉精神分裂症亲属在情绪处理中的神经异常.
- 兄弟姐妹中右桃体-右骨连接性增加可能代表一个补偿机制.
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