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一个Toll7-1-Spätzle7-1通道在Spodoptera litura中对抗Bacillus thuringiensis的病毒

Jin Li¹, Wan-Ting Wei¹, Jia-Hao Xiang¹

¹Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, China.

Pest management science

|February 18, 2026

概括

在Spodoptera litura中的Toll7-1-Spz7-1通路对于昆虫对Bacillus thuringiensis (Bt) 的免疫是至关重要的. 这项研究阐明了托尔/托尔类受体 (TLR) 亚型在昆虫防御机制中的作用.

科学领域:

昆虫学昆虫学是一门学科.
免疫学免疫学免疫学
基因组学就是基因组学.

背景情况:

昆虫免疫对于对抗诸如Bacillus thuringiensis (Bt) 这样的病原体至关重要.
收费/收费类受体 (TLR) 途径在Bt防御中的作用尚不清楚.
单一氨酸集群 (scc) 和多重氨酸集群 (mcc) 之间的功能差异需要调查.

研究的目的:

在Spodoptera litura中识别和分类Toll和Spatzle基因.
调查Toll/TLR亚型在防范Bt.的具体作用.
探索mcc-和scc-Tolls/TLRs的进化多样化.

主要方法:

对Toll和Spatzle基因的全基因组遗传学分析.
对基因选择,结构和染色体组织的分析.
蛋白质与蛋白质相互作用和分子对接研究.
用于基因淘汰和基因表达分析的RNA干扰 (RNAi).

主要成果:

在S. litura中确定了12个Toll和12个Spatzle基因;mccTolls是无内基的和集群的.
麦克托尔表现出更广泛的联结特异性.
在Bt毒素暴露后,Toll7-1-Spz7-1通路在中肠上升调节.
淘汰Toll7-1或Spz7-1增加了对Bt的敏感性和抑制了抗微生物 (AMP) 基因表达.

结论:

这条Toll7-1-Spz7-1通路对于S. litura对B. thuringiensis的防御至关重要.
这些发现提供了对mcc和scc-Tolls/TLRs多样化的进化见解.

关键词:

细菌 thuringiensis 这种疾病.这是一种Bt毒素.在这里,我们可以看到 Spätzlele.有关收费的收费.昆虫免疫力昆虫免疫力

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