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Updated: Jun 14, 2026

Modified Annexin V/Propidium Iodide Apoptosis Assay For Accurate Assessment of Cell Death
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cGAS-IFN-I反应通过通过核细胞分解从垂死的细胞中提取核DNA

Hideo Negishi1,2,3,4, Yusuke Wada5, Yoshitaka Shirasaki6

  • 1Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. hnegishi@ims.u-tokyo.ac.jp.

Nature communications
|February 18, 2026
PubMed
概括

巨细胞通过核细胞分裂从垂死的细胞中提取核DNA,激活cGAS-STING-IFN-I通路. 这一与 lysosomal 功能障碍相关的过程,为炎症性疾病提供了目标.

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.