细胞与细胞之间的沟通作为底层原则,控制着远鱼的颜色模式形成
Marleen Klann1, Saori Miura1, Shu-Hua Lee2
1Marine Eco-Evo-Devo Unit, Okinawa Institute of Science and Technology, Okinawa, Japan.
Nature communications
|February 18, 2026
概括
鱼的缺口连接通信变化通过影响细胞边界来破坏色素模式. 这揭示了动物色彩多样性的灵活机制.
科学领域:
- 发展生物学 发展生物学
- 遗传学 是一个遗传学.
- 动物颜料化动物颜料化
背景情况:
- 动物的色素模式对于生存和表现至关重要.
- 鱼类模式变化的机制尚未完全理解.
- 图灵模型解释了斑马鱼的条纹,但对其他鱼类的适用性尚不清楚.
研究的目的:
- 在鱼中调查雪花突变变异型的遗传基础.
- 确定细胞间通信在色素模式形成中的作用.
- 探索色素模式多样化的保守与灵活机制.
主要方法:
- 全基因组关联映射和有针对性的测序以识别突变.
- 基因功能验证的CRISPR/Cas9基因组编辑.
- 差距结合的药理抑制,以评估沟通角色.
- 在体外测试以评估蛋白质功能和表达分析.
主要成果:
- 在gja5b (Connexin 41.8) 中的一种误解突变 (E42K) 导致了雪花表型.
- 缺陷的间隙连接通信是不规则的色素边界的基础.
- 鱼gja5b主要表达在 iridophores 中,与斑马鱼不同.
- 突变以一种主导负态的方式起作用,减少间隙结合合.
结论:
- 间隙连接介导的通信是一种控制色素模式的保存机制.
- 细胞间通信在色素边界定位和多样化方面发挥着灵活的作用.
- 这些发现提供了关于动物色彩演变的见解.
相关概念视频
Overview of Cell Signaling
25.3K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
25.3K
Osmoregulation in Fishes
53.4K
When cells are placed in a hypotonic (low-salt) fluid, they can swell and burst. Meanwhile, cells in a hypertonic solution—with a higher salt concentration—can shrivel and die. How do fish cells avoid these gruesome fates in hypotonic freshwater or hypertonic seawater environments?
53.4K
Position-effect Variegation
7.2K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.2K
Channel Rhodopsins
3.3K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
3.3K
What is Cell Signaling?
131.3K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
131.3K


