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Updated: Feb 20, 2026

Measuring Single-Cell Mitochondrial DNA Copy Number and Heteroplasmy Using Digital Droplet Polymerase Chain Reaction
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线粒体异质体是慢性淋巴细胞白血病发展的危险因素

Sergiu Pasca1, Yun Soo Hong2,3, Wen Shi2

  • 1Division of Hematological Malignancies, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.

Nature communications
|February 18, 2026
PubMed
概括

线粒体异质体预测慢性淋巴细胞白血病 (CLL) 的风险,即使没有可检测的L-CHIP. 有害变异显著增加了CLL风险,为早期检测提供了一个新的生物标志物.

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