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Updated: Feb 20, 2026

G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay
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Published on: September 10, 2016

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合规生物传感器通过GPCRs划出了内体G蛋白调节的界限

Brian Wysolmerski1,2, Nicole M Fisher1, Andrew N Dates1

  • 1Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.

Nature communications
|February 18, 2026
PubMed
概括

G蛋白结合受体 (GPCRs) 将Gαs移动到内体,以持续发送信号,但活动需要内部化. 这项研究揭示了独特的血和内体GPCR-G蛋白合机制,控制Gs度和活性.

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