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相关概念视频

Longitudinal Research02:20

Longitudinal Research

13.5K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Longitudinal Studies01:26

Longitudinal Studies

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Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
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相关实验视频

Updated: Feb 20, 2026

Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
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纵向大脑年龄预测包括长期太空飞行任务.

Ge Tang1,2, Kaustubh R Patil3,4, Felix Hoffstaedter3,4

  • 1Institute for Neuroradiology, University Hospital, LMU Munich, Munich, Germany. ge.tang@campus.lmu.de.

NPJ microgravity
|February 18, 2026
PubMed
概括

长时间的太空飞行可能会加速大脑衰老. 我们的研究发现宇航员和对照人员之间大脑年龄存在差异,飞行前的大脑年龄比飞行后的大脑年龄更小.

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科学领域:

  • 神经科学是一个神经科学.
  • 太空医学 太空医学
  • 放射学 放射学是一门学科.

背景情况:

  • 了解太空旅行对人体的生理影响至关重要.
  • 长时间的太空飞行对宇航员健康构成独特的挑战,包括对大脑的潜在影响.

研究的目的:

  • 为了研究长时间太空飞行对宇航员大脑衰老的影响.
  • 为了比较太空人 (ROS宇航员和ESA宇航员) 的大脑衰老与地球控制器.

主要方法:

  • 结构性MRI扫描是在飞行前,飞行后和随访期间获得的.
  • 机器学习模型被用来从MRI数据估计大脑年龄.
  • 分析了俄罗斯 (ROS) 和欧洲 (ESA) 宇航员和匹配的控制器的数据.

主要成果:

  • 在太空人和对照人之间观察到大脑衰老的显著差异,特别是在ESA队列中 (ß = 0.63).
  • 在ROS队列中,在飞行前和飞行后扫描之间注意到了差异,飞行后的大脑年龄大约比飞行前大约0.842年.
  • 机器学习模型在MRI会话中表现出良好的至极好的可靠性 (ICC).

结论:

  • 长时间的太空飞行似乎影响了人类大脑的衰老.
  • 需要进一步的研究来充分阐明太空旅行的神经生物学后果.