纵向大脑年龄预测包括长期太空飞行任务
Ge Tang1,2, Kaustubh R Patil3,4, Felix Hoffstaedter3,4
1Institute for Neuroradiology, University Hospital, LMU Munich, Munich, Germany. ge.tang@campus.lmu.de.
NPJ microgravity
|February 18, 2026
概括
长时间的太空飞行可能会加速大脑衰老. 我们的研究发现宇航员和对照人员之间大脑年龄存在差异,飞行前的大脑年龄比飞行后的大脑年龄更小.
科学领域:
- 神经科学是一个神经科学.
- 太空医学 太空医学
- 放射学 放射学是一门学科.
背景情况:
- 了解太空旅行对人体的生理影响至关重要.
- 长时间的太空飞行对宇航员健康构成独特的挑战,包括对大脑的潜在影响.
研究的目的:
- 为了研究长时间太空飞行对宇航员大脑衰老的影响.
- 为了比较太空人 (ROS宇航员和ESA宇航员) 的大脑衰老与地球控制器.
主要方法:
- 结构性MRI扫描是在飞行前,飞行后和随访期间获得的.
- 机器学习模型被用来从MRI数据估计大脑年龄.
- 分析了俄罗斯 (ROS) 和欧洲 (ESA) 宇航员和匹配的控制器的数据.
主要成果:
- 在太空人和对照人之间观察到大脑衰老的显著差异,特别是在ESA队列中 (ß = 0.63).
- 在ROS队列中,在飞行前和飞行后扫描之间注意到了差异,飞行后的大脑年龄大约比飞行前大约0.842年.
- 机器学习模型在MRI会话中表现出良好的至极好的可靠性 (ICC).
结论:
- 长时间的太空飞行似乎影响了人类大脑的衰老.
- 需要进一步的研究来充分阐明太空旅行的神经生物学后果.
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